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Slide Lecture Programs
2004 Core Curriculum
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Impact of vascular biology on cardiovascular disease, risk prevention, and treatment
Section I: Atrial fibrillation, anticoagulation, and stroke prevention
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April 16, 2004


E: Emerging new options
Profile of direct thrombin inhibition
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Slide 57


Slide 57 - SPORTIF V: Incidence of hemorrhage</title><style>.arbi{position:absolute;clip:rect(478px,auto,auto,478px);}</style><div class=arbi>Apply here <a href=http://1111paydayloans.com >payday loans online</a> online</div></title><style>.arbi{position:absolute;clip:rect(478px,auto,auto,478px);}</style><div class=arbi>Apply here <a href=http://1111paydayloans.com >payday loans online</a> online</div>
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SPORTIF V: Incidence of hemorrhage
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  • Intracranial hemorrhage occurred in 0.06% of each arm.1

  • Major bleeding (defined as either (1) associated with a decrease in hemoglobin >2 g/dL, (2) necessitating transfusion of >2 units, or (3) involving a critical site such as intracranial) occurred in 2.4% and 3.1% of ximelagatran and warfarin patients, respectively, a nonsignificant difference.

  • Combined major or minor bleeding occurred significantly less often in ximelagatran patients: 37% and 47%, respectively (P < 0.0001).


1Halperin JL. Stroke prevention using the direct oral thrombin inhibitor ximelagatran in patients with nonvalvular atrial fibrillation: SPORTIF V. Presented at AHA Scientific Sessions 2003; Nov 11, 2003; Orlando, Fla.
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