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| Slide Lecture Programs |
| 2000 Core Curriculum |
| The endothelium: New insights into the origins and treatment of CAD |
August 31, 2000
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| VIII: |
The tissue ACE trials
- In the HOPE study, ACE inhibition was associated with significant risk reductions when each of the outcomes was analyzed separately.99
- Risk reductions included:
- Cardiovascular death 25% (P < .001)
- Nonfatal MI 20% (P < .001)
- Stroke 31% (P < .001)
- Revascularization (CABG or PTCA) 16%(P < .001)
- New onset diabetes 32% (P < .002)
- It was postulated that the beneficial effects with regard to new onset diabetes may have been mediated by improved insulin sensitivity, a decrease in hepatic clearance of insulin, an anti-inflammatory effect, improved blood flow to the pancreas, or an effect on abdominal fat.
- The HOPE investigators comment that treatment of 1000 patients for 4 years prevents about 150 events in approximately 70 patients.
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