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| Slide Lecture Programs |
| 2006 Core Curriculum |
| Targeting Insulin Resistance for Vascular Protection |
July 31, 2006
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Targeting Insulin Resistance for Vascular Protection
- Recent data indicate that heart disease risk begins at blood glucose levels considered to be normal (<96 mg/dL).
- Brunner et al examined the relationship between 2-hour postload glucose levels and coronary heart disease (CHD) mortality over 33 years in 17,869 men, aged 40-64 years.
- Beginning at 83 mg/dL, rising glucose levels correlated linearly with CHD mortality (vertical bars indicate standard error).
- The data are consistent with recent meta-analyses showing a correlation between CV risk and glucose levels below the diabetic threshold, thus driving evidence that CV risk in diabetes occurs within normal range.1
- Coutinho M et al. Diabetes Care. 1999;22:233-40.
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