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| Slide Lecture Programs |
| 2007 Core Curriculum |
| Myocardial Ischemia Redefined: Optimal Care in CAD |
October 9, 2007
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| III: |
Clinical Trial Update |
Slide 39 |
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Antianginal efficacy by gender
- Although exercise duration improved from baseline in men and women at all ranolazine doses studied, women showed less improvement than men.
- The treatment-by-gender interaction was not significant in either study, possibly because the power of the test for interaction was limited by the small number of women in the studies (27% in MARISA and 22% in CARISA).
- The P values in the MARISA study are for comparison of the study drug with placebo; the P values in the CARISA study are for comparison of the study drug with placebo (analysis of covariance).
- The predominant reason for stopping the exercise test in women and men was angina.
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