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| Slide Lecture Programs |
| 2007 Core Curriculum |
| Myocardial Ischemia Redefined: Optimal Care in CAD |
October 9, 2007
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| III: |
Clinical Trial Update |
Slide 68 |
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COURAGE: Study design
- COURAGE was a multicenter trial of patients with documented ischemia and angiographically confirmed single or multivessel CAD:
- Stenosis of at least 70% in at least one proximal epicardial artery and objective evidence of myocardial ischemia
- One coronary stenosis of at least 80% and classic angina without provocative testing
- A total of 2287 patients were randomized to a strategy of PCI plus optimal medical therapy (ie, intensive pharmacologic therapy plus lifestyle intervention) (n = 1149) or optimal medical therapy alone (n = 1138).
- The primary outcome was death from any cause and nonfatal MI.
- The secondary outcome was a composite of death, nonfatal MI, and stroke.
- The median follow-up period was 4.6 years.
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