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| Slide Lecture Programs |
| 2004 Core Curriculum |
Impact of vascular biology on cardiovascular disease, risk prevention, and treatment
Section IV: RAAS manipulation and cardiovascular risk |
August 27, 2004
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Risk reduction in diabetes: Focus on preclinical disease |
Slide 37 |
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Fatal/nonfatal CHD events in patients with/without history of MI or diabetes
- Lee et al followed 13,790 US men and women enrolled in the Atherosclerosis Risk In Communities (ARIC) study.1 Subjects were ages 45 to 64 years at baseline. The average follow-up was 9 years.
- hown, patients with diabetes and without prior MI were at higher risk than patients free from MI and diabetes, but were at lower risk than those with prior MI and no diabetes.
- Compared with patients with diabetes and no prior MI, patients with prior MI and no diabetes had 1.9 times the risk of fatal/nonfatal coronary heart disease (CHD) events (95% CI, 1.22 to 2.72; P = 0.003).
- The ARIC data contrast with an earlier study in a Finnish population, which found that diabetes was associated with a similar risk of CHD events as prior MI (see slide #169 in the VBWG Core Curriculum 2001).2
- The ARIC data suggest that there may be a role for risk stratification in patients with diabetes.
1Lee CD, Folsom AR, Pankow JS, Brancati FL, for the Atherosclerosis Risk In Communities (ARIC) Study Investigators. Cardiovascular events in diabetic and nondiabetic adults with or without history of myocardial infarction. Circulation. 2004;109:855-860.
2Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med. 1998;339:229-234.
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