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| Slide Lecture Programs |
| 2004 Core Curriculum |
Impact of vascular biology on cardiovascular disease, risk prevention, and treatment
Section IV: RAAS manipulation and cardiovascular risk |
August 27, 2004
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| E: |
Risk reduction in diabetes: Focus on preclinical disease |
Slide 41 |
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LIFE: Continuous relation of albuminuria to primary outcome
in patients with diabetes
- A recent substudy of the LIFE study evaluated the relation of albuminuria in hypertensive patients with LVH.1 Baseline albuminuria determinations were available for 8206 (89%) of LIFE participants. The slides shows data obtained from the cohort of 1063 patients with coexisting diabetes.
- Risk for the composite CV outcome (CV death, MI, stroke) rose continuously as albuminuria increased. There was no specific threshold for increased risk.
- For every 10-fold increase in the ratio of urinary albumin to creatinine, the hazard ratio increased as follows:
- Composite endpoint, 39% (P = 0.001)
- CV mortality, 46.9% (P = 0.009)
- All-cause mortality, 38.3% (P = 0.005)
- Stroke, 37.3% (P = 0.025)
- For MI, the trend was weaker and nonsignificant (20% increase, P > 0.2).
1Wachtell K, Ibsen H, Olsen MH, Borch-Johnsen K, Lindholm LH, Mogensen CE, et al. Albuminuria and cardiovascular risk in hypertensive patients with left ventricular hypertrophy: The LIFE study. Ann Intern Med. 2003;139:901-906.
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