| |
|
|
|
|
| Slide Lecture Programs |
| 2004 Core Curriculum |
Impact of vascular biology on cardiovascular disease, risk prevention, and treatment
Section IV: RAAS manipulation and cardiovascular risk |
August 27, 2004
|
| E: |
Risk reduction in diabetes: Focus on preclinical disease |
Slide 44 |
|
Download PowerPoint
|
Increased RAAS activity in diabetic nephropathy
- Activation of the renal RAAS also occurs in diabetes. Mezzano et al conducted a histochemical analysis of kidney biopsies from 10 patients with diabetes and overt nephropathy and 5 nondiabetic controls (normal) undergoing surgery for localized renal tumors.1
- As shown, ACE and Ang II were weakly expressed in the brush border of proximal tubules in the control group. In contrast, samples from diabetic subjects showed marked upregulation and more widespread distribution.
1Mezzano S, Droguett A, Burgos E, Ardiles LG, Flores CA, Aros CA, et al. Renin-angiotensin system activation and interstitial inflammation in human diabetic nephropathy. Kidney Int Suppl. 2003;64(supp 86):S64-S70.
|
|
|
Resources
