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| Slide Lecture Programs |
| 2004 Core Curriculum |
Impact of vascular biology on cardiovascular disease, risk prevention, and treatment
Section IV: RAAS manipulation and cardiovascular risk |
August 27, 2004
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| E: |
Risk reduction in diabetes: Focus on preclinical disease |
Slide 45 |
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NF- kB activation in diabetic nephropathy
- Mezzano et al also demonstrated activation of nuclear factor-kappa B (NF-kB).1 Activated NF-kB was mainly detected in tubular epithelial cells and, to a lesser extent, in glomerular and interstitial cells.
- Oxidative stress, which occurs early in the progression of insulin resistance to diabetes, activates NF-kB. The data from Mezzano et al implicate renal RAAS activation as another mechanism for NF-kB activation.
1Mezzano S, Droguett A, Burgos E, Ardiles LG, Flores CA, Aros CA, et al. Renin-angiotensin system activation and interstitial inflammation in human diabetic nephropathy. Kidney Int Suppl. 2003;64(supp 86):S64-S70.
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