• The Global Registry of Acute Coronary Events (GRACE) study found marked geographic variations in antithrombotic and interventional strategies for management of acute coronary syndromes (ACS).¹

• Use of percutaneous coronary intervention (PCI) and glycoprotein (GP) IIb/IIIa inhibitors is relatively higher in the United States compared with other geographic regions. In contrast, use of low-molecular-weight heparin (LMWH) is much lower compared with other regions.

• As shown herein, data support an expanded role for LMWH in ACS in the United States, particularly in the setting of PCI.

¹ Fox KAA, Goodman SG, Klein W, Brieger D, Steg PG, Dabbous O, Avezum A. Management of acute coronary syndromes. Variations in practice and outcome. Findings from the Global Registry of Acute Coronary Events (GRACE). Eur Heart J. 2002;23:1177-1189.