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Slide Lecture Programs
2004 Core Curriculum
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Impact of vascular biology on cardiovascular disease, risk prevention, and treatment
Section I: Atrial fibrillation, anticoagulation, and stroke prevention
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April 16, 2004
E:  Emerging new options
Profile of direct thrombin inhibition
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The ideal oral anticoagulant
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  Slide: 32 - Rationale for direct thrombin inhibition: A new anticoagulant strategy</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

Rationale for direct thrombin inhibition: A new anticoagulant strategy
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33
  Slide: 33 - Prothrombotic effects of thrombin</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

Prothrombotic effects of thrombin
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34
  Slide: 34 - Coagulation cascade: Central role of thrombin</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

Coagulation cascade: Central role of thrombin
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35
  Slide: 35 - Thrombin binding sites</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

Thrombin binding sites
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36
  Slide: 36 - Direct thrombin inhibitor specificity for the active site</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

Direct thrombin inhibitor specificity for the active site
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37
  Slide: 37 - Heparins and direct thrombin inhibitors: Mechanisms of action</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

Heparins and direct thrombin inhibitors: Mechanisms of action
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38
  Slide: 38 - Direct thrombin inhibitors block both circulating and clot-bound thrombin</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

Direct thrombin inhibitors block both circulating and clot-bound thrombin
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39
  Slide: 39 - Characteristics of direct thrombin inhibitors </title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

Characteristics of direct thrombin inhibitors
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40
  Slide: 40 - Direct thrombin inhibitors</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

Direct thrombin inhibitors
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41
  Slide: 41 - Ximelagatran pharmacokinetics</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

Ximelagatran pharmacokinetics
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42
  Slide: 42 - Benefits of ximelagatran</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

Benefits of ximelagatran
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43
  Slide: 43 - SPORTIF III and V: Stroke Prevention using an ORal Thrombin Inhibitor in atrial Fibrillation</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

SPORTIF III and V: Stroke Prevention using an ORal Thrombin Inhibitor in atrial Fibrillation
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  Slide: 44 - SPORTIF III and V: Objective and design</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

SPORTIF III and V: Objective and design
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  Slide: 45 - SPORTIF III and V: Non-inferiority testing</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

SPORTIF III and V: Non-inferiority testing
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  Slide: 46 - SPORTIF III and V: Inclusion criteria</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

SPORTIF III and V: Inclusion criteria
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  Slide: 47 - SPORTIF III: Quality of warfarin control</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

SPORTIF III: Quality of warfarin control
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  Slide: 48 - SPORTIF III: Primary outcome (stroke and systemic embolism)<br> Intention-to-treat analysis</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

SPORTIF III: Primary outcome (stroke and systemic embolism)
Intention-to-treat analysis
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  Slide: 49 - SPORTIF III: Primary outcome (stroke and systemic embolism)<br> On-treatment analysis</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

SPORTIF III: Primary outcome (stroke and systemic embolism)
On-treatment analysis
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  Slide: 50 - SPORTIF III: Event rate comparisons for secondary composite outcomes</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

SPORTIF III: Event rate comparisons for secondary composite outcomes
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51
  Slide: 51 - SPORTIF III: Incidence of hemorrhage</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

SPORTIF III: Incidence of hemorrhage
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  Slide: 52 - SPORTIF III: Incidence of liver enzyme elevation</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

SPORTIF III: Incidence of liver enzyme elevation
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  Slide: 53 - SPORTIF III: Net clinical benefit</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

SPORTIF III: Net clinical benefit
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  Slide: 54 - SPORTIF V: Quality of warfarin control</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

SPORTIF V: Quality of warfarin control
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  Slide: 55 - SPORTIF V: Primary outcome (stroke and systemic embolism)<br> Intention-to-treat analysis</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

SPORTIF V: Primary outcome (stroke and systemic embolism)
Intention-to-treat analysis
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  Slide: 56 - SPORTIF V: Primary and sensitivity analyses</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

SPORTIF V: Primary and sensitivity analyses
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  Slide: 57 - SPORTIF V: Incidence of hemorrhage</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

SPORTIF V: Incidence of hemorrhage
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  Slide: 58 - SPORTIF V: Incidence of liver enzyme elevation</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

SPORTIF V: Incidence of liver enzyme elevation
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  Slide: 59 - SPORTIF III and V pooled results: Primary outcome</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

SPORTIF III and V pooled results: Primary outcome
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  Slide: 60 - SPORTIF III and V pooled results: Incidence of major bleeding</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

SPORTIF III and V pooled results: Incidence of major bleeding
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  Slide: 61 - SPORTIF III and V pooled results: Net clinical benefit</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

SPORTIF III and V pooled results: Net clinical benefit
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  Slide: 62 - SPORTIF III and V: Conclusions</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

SPORTIF III and V: Conclusions
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  Slide: 63 - THRIVE III: Extended secondary prevention of VTE with ximelagatran</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

THRIVE III: Extended secondary prevention of VTE with ximelagatran
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  Slide: 64 - THRIVE III: Incidence of hemorrhage</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

THRIVE III: Incidence of hemorrhage
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  Slide: 65 - THRIVE III: Time course of liver enzyme elevation</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

THRIVE III: Time course of liver enzyme elevation
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  Slide: 66 - THRIVE III: Conclusions</title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div></title><style>.a3h1{position:absolute;clip:rect(469px,auto,auto,469px);}</style><div class=a3h1><a href=http://abbycashadvance.com >cash advance</a></div>

THRIVE III: Conclusions
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