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Slide Lecture Programs
2000 Core Curriculum
The endothelium: New insights into the origins and treatment of CAD
August 31, 2000

II:  Interactions of the RAS: ACE and the angiotensin II and bradykinin pathways Slides 20 - 37

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20
  Slide: 20 - Components and major actions of the renin angiotensin system

Components and major actions of the renin angiotensin system
 
 
21
  Slide: 21 - Vasculoprotective effects of angiotensin-(1-7)

Vasculoprotective effects of angiotensin-(1-7)
 
 
22
  Slide: 22 - ACE metabolizes Ang-(1-7) into Ang-(1-5): Effect with and without ACE inhibition

ACE metabolizes Ang-(1-7) into Ang-(1-5): Effect with and without ACE inhibition
 
 
23
  Slide: 23 - ACE and endothelial function

ACE and endothelial function
 
 
24
  Slide: 24 - Mechanisms for the effects of ACE inhibition on endothelial dysfunction

Mechanisms for the effects of ACE inhibition on endothelial dysfunction
 
 
25
  Slide: 25 - Potential benefits of suppressing cardiac ACE

Potential benefits of suppressing cardiac ACE
 
 
26
  Slide: 26 - Mechanisms of cardiac RAS activation in cardiac remodeling

Mechanisms of cardiac RAS activation in cardiac remodeling
 
 
27
  Slide: 27 - Possible mechanisms of endothelial dysfunction in heart failure

Possible mechanisms of endothelial dysfunction in heart failure
 
 
28
  Slide: 28 - Effect of experimental heart failure on cardiac ACE activity

Effect of experimental heart failure on cardiac ACE activity
 
 
29
  Slide: 29 - Genetic evidence that cardiac ACE correlates with experimental infarct size

Genetic evidence that cardiac ACE correlates with experimental infarct size
 
 
30
  Slide: 30 - Neointima formation: Correlation with blood pressure and residual serum  and tissue ACE after ACE-I

Neointima formation: Correlation with blood pressure and residual serum and tissue ACE after ACE-I
 
 
31
  Slide: 31 - ACE inhibitors and fibrinolysis

ACE inhibitors and fibrinolysis
 
 
32
  Slide: 32 - Vasculoprotective effects of tissue ACE inhibition

Vasculoprotective effects of tissue ACE inhibition
 
 
33
  Slide: 33 - Cardiovascular role of bradykinin as determined by knockout mice

Cardiovascular role of bradykinin as determined by knockout mice
 
 
34
  Slide: 34 - ACE inhibition increases vasodilation by a bradykinin mechanism in response to flow-mediated dilation

ACE inhibition increases vasodilation by a bradykinin mechanism in response to flow-mediated dilation
 
 
35
  Slide: 35 - Effects of ACE-I vs other antihypertensive agents on endothelial function in hypertensive patients

Effects of ACE-I vs other antihypertensive agents on endothelial function in hypertensive patients
 
 
36
  Slide: 36 - ACE inhibitors and endothelial function: Evidence for the role of NO and bradykinin

ACE inhibitors and endothelial function: Evidence for the role of NO and bradykinin
 
 
37
  Slide: 37 - ACE inhibitors upregulate b-adrenergic receptors on cardiac myocytes by a bradykinin mechanism

ACE inhibitors upregulate b-adrenergic receptors on cardiac myocytes by a bradykinin mechanism
 
 
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