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Slide Lecture Programs
2007 Core Curriculum
Myocardial Ischemia Redefined: Optimal Care in CAD
October 9, 2007

III:  Clinical Trial Update Slides 28 - 78

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28
  Slide: 28 - Clinical Trial Update

Clinical Trial Update
 
 
29
  Slide: 29 - Issues in chronic myocardial ischemia treatment

Issues in chronic myocardial ischemia treatment
 
 
30
  Slide: 30 - Stable CAD: Multiple treatment options

Stable CAD: Multiple treatment options
 
 
31
  Slide: 31 - SAFE-LIFE: Evaluation of intensive lifestyle intervention

SAFE-LIFE: Evaluation of intensive lifestyle intervention
 
 
32
  Slide: 32 - SAFE-LIFE: Reduction in angina at 1 year with intensive lifestyle intervention

SAFE-LIFE: Reduction in angina at 1 year with intensive lifestyle intervention
 
 
33
  Slide: 33 - Chronic ischemic heart disease: Treatment gaps

Chronic ischemic heart disease: Treatment gaps
 
 
34
  Slide: 34 - Novel anti-ischemic strategy

Novel anti-ischemic strategy
 
 
35
  Slide: 35 - Ranolazine clinical trial program

Ranolazine clinical trial program
 
 
36
  Slide: 36 - Ranolazine clinical trial program in chronic stable angina

Ranolazine clinical trial program in chronic stable angina
 
 
37
  Slide: 37 - MARISA, CARISA, ERICA main findings

MARISA, CARISA, ERICA main findings
 
 
38
  Slide: 38 - Challenges in selected populations: Experience with ranolazine

Challenges in selected populations: Experience with ranolazine
 
 
39
  Slide: 39 - Antianginal efficacy by gender

Antianginal efficacy by gender
 
 
40
  Slide: 40 - Antianginal efficacy by gender

Antianginal efficacy by gender
 
 
41
  Slide: 41 - Antianginal efficacy by age

Antianginal efficacy by age
 
 
42
  Slide: 42 - Antianginal efficacy by diabetes status

Antianginal efficacy by diabetes status
 
 
43
  Slide: 43 - CARISA: Reductions in A1C (diabetes substudy)

CARISA: Reductions in A1C (diabetes substudy)
 
 
44
  Slide: 44 - Summary: Ranolazine in challenging populations

Summary: Ranolazine in challenging populations
 
 
45
  Slide: 45 - ROLE: Long-term safety and tolerability in stable CAD patients

ROLE: Long-term safety and tolerability in stable CAD patients
 
 
46
  Slide: 46 - MERLIN-TIMI 36: Study design

MERLIN-TIMI 36: Study design
 
 
47
  Slide: 47 - MERLIN-TIMI 36: Effect on primary endpoint

MERLIN-TIMI 36: Effect on primary endpoint
 
 
48
  Slide: 48 - MERLIN-TIMI 36: Components of primary endpoint

MERLIN-TIMI 36: Components of primary endpoint
 
 
49
  Slide: 49 - MERLIN-TIMI 36: Efficacy results in major subgroups

MERLIN-TIMI 36: Efficacy results in major subgroups
 
 
50
  Slide: 50 - MERLIN-TIMI 36: Primary arrhythmia endpoints

MERLIN-TIMI 36: Primary arrhythmia endpoints
 
 
51
  Slide: 51 - MERLIN-TIMI 36: Reduction in VT lasting 8 beats or more

MERLIN-TIMI 36: Reduction in VT lasting 8 beats or more
 
 
52
  Slide: 52 - MERLIN-TIMI 36: Incidence of VT = 8 beats or more in high-risk subgroups

MERLIN-TIMI 36: Incidence of VT = 8 beats or more in high-risk subgroups
 
 
53
  Slide: 53 - MERLIN-TIMI 36: Ventricular tachycardia events

MERLIN-TIMI 36: Ventricular tachycardia events
 
 
54
  Slide: 54 - MERLIN-TIMI 36: Major safety outcomes

MERLIN-TIMI 36: Major safety outcomes
 
 
55
  Slide: 55 - MERLIN-TIMI 36: Sudden cardiac death by subgroup

MERLIN-TIMI 36: Sudden cardiac death by subgroup
 
 
56
  Slide: 56 - MERLIN-TIMI 36: Summary and implications

MERLIN-TIMI 36: Summary and implications
 
 
57
  Slide: 57 - Stable CAD: Multiple treatment options

Stable CAD: Multiple treatment options
 
 
58
  Slide: 58 - ACIP: Study design

ACIP: Study design
 
 
59
  Slide: 59 - ACIP: Baseline characteristics

ACIP: Baseline characteristics
 
 
60
  Slide: 60 - ACIP: Two-year cumulative all-cause mortality rates for the treatment strategies

ACIP: Two-year cumulative all-cause mortality rates for the treatment strategies
 
 
61
  Slide: 61 - SWISSI II: Study design

SWISSI II: Study design
 
 
62
  Slide: 62 - SWISSI II: Baseline characteristics

SWISSI II: Baseline characteristics
 
 
63
  Slide: 63 - SWISSI II: Treatment effect on primary outcome

SWISSI II: Treatment effect on primary outcome
 
 
64
  Slide: 64 - ACIP, SWISSI II: Summary and implications

ACIP, SWISSI II: Summary and implications
 
 
65
  Slide: 65 - COURAGE: Defining optimal care

COURAGE: Defining optimal care
 
 
66
  Slide: 66 - What is the definitive role of PCI in chronic angina and stable CAD?

What is the definitive role of PCI in chronic angina and stable CAD?
 
 
67
  Slide: 67 - Patient expectations about elective PCI for stable CAD

Patient expectations about elective PCI for stable CAD
 
 
68
  Slide: 68 - COURAGE: Study design

COURAGE: Study design
 
 
69
  Slide: 69 - COURAGE: Lifestyle intervention and risk factor goals

COURAGE: Lifestyle intervention and risk factor goals
 
 
70
  Slide: 70 - COURAGE: Pharmacologic therapy

COURAGE: Pharmacologic therapy
 
 
71
  Slide: 71 - COURAGE: Baseline angiographic data

COURAGE: Baseline angiographic data
 
 
72
  Slide: 72 - COURAGE: Baseline angina

COURAGE: Baseline angina
 
 
73
  Slide: 73 - COURAGE: Inducible ischemia at baseline

COURAGE: Inducible ischemia at baseline
 
 
74
  Slide: 74 - COURAGE: Treatment effect on primary outcome

COURAGE: Treatment effect on primary outcome
 
 
75
  Slide: 75 - COURAGE: Treatment effect on angina

COURAGE: Treatment effect on angina
 
 
76
  Slide: 76 - COURAGE: Treatment effect in CV and diabetes subgroups

COURAGE: Treatment effect in CV and diabetes subgroups
 
 
77
  Slide: 77 - COURAGE: Change in quality-of-life scores

COURAGE: Change in quality-of-life scores
 
 
78
  Slide: 78 - COURAGE: Summary and implications

COURAGE: Summary and implications
 
 
 
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