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Slide Lecture Programs
2003 Core Curriculum
Impact of vascular biology in treatment of cardiovascular disease
Section III: Neurohormonal strategies in the failing heart
May 3, 2003


Table of Contents - 50 slides

No.  Title
1  Heart failure: US statistics
2  The comparative cost of heart failure
3  High lifetime risk of heart failure
4  Strategies to prevent/reverse HF progression
5  Role of RAAS and SNS in HF progression
6  Combination ACEI and ß-blockade enhances RAAS inhibition in patients with HF
7  ß-Blockade blunts stress-related increase in coronary atherosclerosis in monkeys
8  ß-Blocker Cholesterol-lowering Asymptomatic Plaque Study (BCAPS): Study design
9  BCAPS: Change in carotid artery bulb IMT during 3-year follow-up
10  ELVA: Study design
11  ELVA: ß-Blockade decreases atherosclerotic progression in carotid IMT composite
12  Results from Heart Protection Study: First major vascular event (coronary event, stroke, revascularization) - Interaction of statins with ß-blockers
13  Hypothesis: ß-Blockade improves myocardial function and reverses remodeling by altering cardiac myocyte gene expression
14  Myocardial gene expression in dilated cardiomyopathy in response to ß-blocker therapy
15  Hypothetical mechanism of ß-blocker induced improvement in myocardial function and reversal of remodeling
16  Potential consequences of inflammation in heart failure
17  Potential associations of early ß-blockade
18  Survival studies of ß-blockade in heart failure
19  MERIT-HF: Reduction in total mortality and hospitalizations in women receiving ß-blockade
20  MERIT-HF: Efficacy of ß-blockade in elderly patients with heart failure
21  COPERNICUS: Effect of ß-blockade in patients with severe HF by sex and age
22  MERIT-HF: Effects of ß-blockade on mortality in post-MI and hypertensive patient subgroups
23  MERIT-HF: Effect of ß-blockade on total mortality or HF hospitalization in diabetic and nondiabetic patients
24  ß-Blocker titration in major HF trials
25  MERIT HF: Discontinuation from study medicine during follow-up
26  MERIT-HF: Consistent heart rate reduction with lower vs higher ß-blocker dose
27  MERIT-HF: Flexible dosing achieves consistent results
28  ß-Blockade modifies circadian pattern of ventricular tachyarrhythmias
29  Sudden death: Risk reduction with ß-blockade
30  MADIT II: Survival with prophylactic ICD in MI patients with EF <30%
31  Predictive power of BNP for HF hospitalization or death
32  Treatment benefits of ß-blockade
33  ß-Blockade for cardioprotection
34  SOLVD: Effect of ß-blockade on mortality in patients with asymptomatic LV systolic dysfunction (post hoc analysis)
35  ACC/AHA heart failure guidelines: Treating asymptomatic patients
36  ACC/AHA heart failure guidelines: Treating symptomatic patients
37  Contemporary therapy for heart failure
38  Effect of ß-blockade on mortality among high-risk post-MI patient subgroups: Observational study
39  Potential role of ß-blockade in survival after percutaneous coronary intervention
40  ß-Blockade after percutaneous coronary intervention: Benefits observed in high-risk subgroups
41  Common misconceptions about ß-blockade
42  ß-Blockade and potential symptoms of depression, fatigue, and sexual dysfunction
43  Expanded options for patients with renal hypertension: AASK study design
44  AASK: Effect of drug intervention on proteinuria
45  AASK: Risk reduction in GFR decline, ESRD, or death-Outcomes with higher proteinuria
46  AASK: BP achieved vs drugs required
47  Trends in cardiac medications of proven benefit in outpatients
48  Secondary prevention medications are underprescribed in women with CAD
49  Morbidity and mortality benefits of ß-blockade in HF: Number needed-to-treat analysis
50  Health and economic impact of increased use of ß-blockers after first MI



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