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Slide Lecture Programs
2003 Core Curriculum
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Impact of vascular biology in treatment of cardiovascular disease
Section III: Neurohormonal strategies in the failing heart
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May 3, 2003
Table of Contents - 50 slides
No.
Title
1
Heart failure: US statistics
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2
The comparative cost of heart failure
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3
High lifetime risk of heart failure
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4
Strategies to prevent/reverse HF progression
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5
Role of RAAS and SNS in HF progression
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6
Combination ACEI and ß-blockade enhances RAAS inhibition in patients with HF
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7
ß-Blockade blunts stress-related increase in coronary atherosclerosis in monkeys
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8
ß-Blocker Cholesterol-lowering Asymptomatic Plaque Study (BCAPS): Study design
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9
BCAPS: Change in carotid artery bulb IMT during 3-year follow-up
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10
ELVA: Study design
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11
ELVA: ß-Blockade decreases atherosclerotic progression in carotid IMT composite
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12
Results from Heart Protection Study: First major vascular event (coronary event, stroke, revascularization) - Interaction of statins with ß-blockers
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13
Hypothesis: ß-Blockade improves myocardial function and reverses remodeling by altering cardiac myocyte gene expression
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14
Myocardial gene expression in dilated cardiomyopathy in response to ß-blocker therapy
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15
Hypothetical mechanism of ß-blocker induced improvement in myocardial function and reversal of remodeling
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16
Potential consequences of inflammation in heart failure
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17
Potential associations of early ß-blockade
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18
Survival studies of ß-blockade in heart failure
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19
MERIT-HF: Reduction in total mortality and hospitalizations in women receiving ß-blockade
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20
MERIT-HF: Efficacy of ß-blockade in elderly patients with heart failure
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21
COPERNICUS: Effect of ß-blockade in patients with severe HF by sex and age
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22
MERIT-HF: Effects of ß-blockade on mortality in post-MI and hypertensive patient subgroups
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23
MERIT-HF: Effect of ß-blockade on total mortality or HF hospitalization in diabetic and nondiabetic patients
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24
ß-Blocker titration in major HF trials
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25
MERIT HF: Discontinuation from study medicine during follow-up
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26
MERIT-HF: Consistent heart rate reduction with lower vs higher ß-blocker dose
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27
MERIT-HF: Flexible dosing achieves consistent results
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28
ß-Blockade modifies circadian pattern of ventricular tachyarrhythmias
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29
Sudden death: Risk reduction with ß-blockade
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30
MADIT II: Survival with prophylactic ICD in MI patients with EF
<
30%
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31
Predictive power of BNP for HF hospitalization or death
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32
Treatment benefits of ß-blockade
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33
ß-Blockade for cardioprotection
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34
SOLVD: Effect of ß-blockade on mortality in patients with asymptomatic LV systolic dysfunction (post hoc analysis)
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35
ACC/AHA heart failure guidelines: Treating asymptomatic patients
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36
ACC/AHA heart failure guidelines: Treating symptomatic patients
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37
Contemporary therapy for heart failure
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38
Effect of ß-blockade on mortality among high-risk post-MI patient subgroups: Observational study
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39
Potential role of ß-blockade in survival after percutaneous coronary intervention
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40
ß-Blockade after percutaneous coronary intervention: Benefits observed in high-risk subgroups
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41
Common misconceptions about ß-blockade
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42
ß-Blockade and potential symptoms of depression, fatigue, and sexual dysfunction
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43
Expanded options for patients with renal hypertension: AASK study design
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44
AASK: Effect of drug intervention on proteinuria
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45
AASK: Risk reduction in GFR decline, ESRD, or death-Outcomes with higher proteinuria
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46
AASK: BP achieved vs drugs required
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47
Trends in cardiac medications of proven benefit in outpatients
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48
Secondary prevention medications are underprescribed in women with CAD
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49
Morbidity and mortality benefits of ß-blockade in HF: Number needed-to-treat analysis
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50
Health and economic impact of increased use of ß-blockers after first MI
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