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Slide Lecture Programs
2003 Core Curriculum
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Impact of vascular biology in treatment of cardiovascular disease
Section IV: Antithrombotic interventions in acute coronary syndromes
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May 28, 2003
Table of Contents - 39 slides
No.
Title
1
CHD-related catheterization
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2
Global variation in hospital management of ACS
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3
Antithrombotic and prothrombotic molecules
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4
Plaque rupture
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5
Thrombotic pathways
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6
Platelet activation
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7
FRISC-II: Sustained benefit of early invasive strategy in UA/NSTEMI
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8
RITA 3: Evidence supporting early interventional strategy in UA/NSTEMI
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9
Model of in-stent restenosis
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10
In-stent restenosis rates
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11
RAVEL: 1-Year survival free of MI or repeat revascularization
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12
TAXUS I: Results at 6 and 12 months
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13
Primary PTCA vs thrombolysis in STEMI
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14
Major actions of antithrombotic agents
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15
Direct thrombin inhibitors in PCI: Peak-activated clotting time by dose (CACHET)
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16
REPLACE-2: Death, MI, urgent revascularization, major bleeding
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17
Proposed model for optimal use of GP IIb/IIIa inhibitors
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18
GP IIb/IIIa inhibitors: Benefit related to revascularization strategy
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19
GP IIb/IIIa inhibitors: Events prevented and number-needed-to-treat by management strategy
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20
Differing effects of anticoagulants on vWF
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21
LMWH inhibits factor VIIa generation and prothrombin activation in vivo
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22
LMWH in PCI: Patients meeting anticoagulant goal at time of procedure
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23
Timecourse of anticoagulation with LMWH (enoxaparin)
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24
Evaluation of LMWH in high-risk UA/NSTEMI
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25
Anticoagulant efficacy in high-risk patients receiving LMWH
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26
Trials of LMWH plus GP Iib/IIIa inhibitors in PCI
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27
NRMI 3: LMWH/UFH plus GP Iib/IIIa inhibitors
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28
INTERACT: LMWH/UFH plus GP Iib/IIIa inhibitor in UA/NSTEMI
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29
INTERACT: LMWH/UFH plus GP Iib/IIIa inhibitor in non-ST-elevation ACS
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30
CRUISE: LMWH/UFH plus GP Iib/IIIa inhibitor in PCI
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31
CRUISE: LMWH/UFH plus GP Iib/IIIa inhibitor in PCI (cont'd)
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32
Consensus algorithm for use of LMWH in PCI
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33
Adverse implications of diabetes in patients with ACS
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34
Adverse impact of diabetes on survival following PCI
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35
ARTS: CABG vs stenting in patients with and without diabetes
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36
EPISTENT: GP IIb/IIIa inhibition reduces target vessel revascularization in diabetics undergoing stenting
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37
1 in 3 NSTEMI patients: Culprit lesion not identified on angiography
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38
ACC/AHA guidelines for UA/NSTEMI: Revascularization in patients with diabetes
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39
ACC/AHA guidelines for UA/NSTEMI: Class I recommendations for antithrombotic therapy
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