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Slide Lecture Programs
2004 Core Curriculum
Impact of vascular biology on cardiovascular disease, risk prevention, and treatment
Section I: Atrial fibrillation, anticoagulation, and stroke prevention
April 16, 2004


Table of Contents - 66 slides

No.  Title
1  Nonvalvular AF: Issues and challenges
2  ATRIA: Prevalence of AF by age and sex
3  ATRIA: Projected number of patients with AF
4  Hospitalizations for AF are increasing
5  Mortality and AF
6  Embolic stroke
7  Stroke risk is increased in AF
8  Severity of stroke with AF
9  Framingham risk score: Relation to 5-year stroke risk
10  Framingham risk score: Relation to 5-year risk of stroke/death
11  Impact of selected AF risk factors on predicted 5-year risk of stroke/death
12  LV systolic dysfunction on echocardiography predicts stroke in AF patients
13  SPAF III: Stroke/systemic embolism event rates according to TEE findings
14  Prothrombotic states in AF
15  Potential prothrombotic mechanisms in AF: ↓ NO production
16  Potential prothrombotic mechanisms in AF: LAA stasis
17  Stroke mechanisms in AF: Proposed unifying model
18  Effect of anticoagulation intensity on post-stroke survival in patients with AF
19  AFFIRM: Effect of anticoagulation intensity on stroke risk
20  ACC/AHA/ESC guidelines for AF management: Newly discovered AF
21  ACC/AHA/ESC guidelines for AF management: Recurrent paroxysmal AF
22  ACC/AHA/ESC guidelines for AF management: Recurrent persistent and permanent AF
23  Warfarin in AF: Stroke risk reductions
24  Aspirin in AF: Stroke risk reductions
25  Oral anticoagulants vs aspirin for stroke prevention in AF
26  Coagulation cascade
27  Anticoagulant action of warfarin: Slow onset
28  Warfarin: Narrow therapeutic window
29  Limitations of warfarin
30  Warfarin limitations lead to under-treatment of AF
31  The ideal oral anticoagulant
32  Rationale for direct thrombin inhibition: A new anticoagulant strategy
33  Prothrombotic effects of thrombin
34  Coagulation cascade: Central role of thrombin
35  Thrombin binding sites
36  Direct thrombin inhibitor specificity for the active site
37  Heparins and direct thrombin inhibitors: Mechanisms of action
38  Direct thrombin inhibitors block both circulating and clot-bound thrombin
39  Characteristics of direct thrombin inhibitors
40  Direct thrombin inhibitors
41  Ximelagatran pharmacokinetics
42  Benefits of ximelagatran
43  SPORTIF III and V: Stroke Prevention using an ORal Thrombin Inhibitor in atrial Fibrillation
44  SPORTIF III and V: Objective and design
45  SPORTIF III and V: Non-inferiority testing
46  SPORTIF III and V: Inclusion criteria
47  SPORTIF III: Quality of warfarin control
48  SPORTIF III: Primary outcome (stroke and systemic embolism)
Intention-to-treat analysis
49  SPORTIF III: Primary outcome (stroke and systemic embolism)
On-treatment analysis
50  SPORTIF III: Event rate comparisons for secondary composite outcomes
51  SPORTIF III: Incidence of hemorrhage
52  SPORTIF III: Incidence of liver enzyme elevation
53  SPORTIF III: Net clinical benefit
54  SPORTIF V: Quality of warfarin control
55  SPORTIF V: Primary outcome (stroke and systemic embolism)
Intention-to-treat analysis
56  SPORTIF V: Primary and sensitivity analyses
57  SPORTIF V: Incidence of hemorrhage
58  SPORTIF V: Incidence of liver enzyme elevation
59  SPORTIF III and V pooled results: Primary outcome
60  SPORTIF III and V pooled results: Incidence of major bleeding
61  SPORTIF III and V pooled results: Net clinical benefit
62  SPORTIF III and V: Conclusions
63  THRIVE III: Extended secondary prevention of VTE with ximelagatran
64  THRIVE III: Incidence of hemorrhage
65  THRIVE III: Time course of liver enzyme elevation
66  THRIVE III: Conclusions



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