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Slide Lecture Programs
Postintervention Continuum of Care: Focus on Lipids
November 1, 1999


Table of Contents - 86 slides

No.  Title
1  Postintervention continuum of care: Focus on lipids
2  Content outline
3  Leading causes of death for all males and females
4  Percentage breakdown of deaths from cardiovascular disease
5  Adjusted rates of in-hospital outcomes after PCI by year of procedure
6  Prevention of stent thrombosis: Overview of key trials
7  Coronary angioplasty vs CABG: Overall survival and survival free from Q-wave MI
8  Coronary angioplasty vs antianginal medical therapy: Greater improvement of angina
9  Current use of PCI
10  Natural history of atherosclerosis and postintervention: Important differences
11  Pathobiologic responses to intervention
12  Postintervention: Two different pathobiologies
13  Management of atherosclerosis and postintervention: Important differences
14  Percentage of patients receiving drug therapy who met NCEP treatment criteria
15  L-TAP: Many high-risk adults are not reaching LDL-C goals
16  L-TAP: Distance from LDL-C goal in patients with > 2 risk factors
17  L-TAP: Distance from LDL-C goal in patients with CHD
18  Cardiologists and primary care physicians: Achieving NCEP goals
19  Cholesterol management by specialty: Physician perceptions vs practice
20  Risk factors and endothelial dysfunction: Mediator role of oxidative stress
21  Mechanisms of oxidative stress
22  Oxidized LDL-C disturbs the endothelium over long-term
23  Some consequences of oxidation of LDL-C
24  Factors in endothelial dysfunction?early stage plaque
25  Factors in endothelial dysfunction?late stage plaque
26  Oxidized LDL-C: A common initiating factor for cardiac events
27  Effect of high-fat meal on endothelial activity in normocholesterolemic patients
28  Endothelial function in patients with and without dyslipidemia
29  Improvement within hours in endothelial function following ischemia with LDL-C apheresis
30  Vitamins C & E attenuate reduction in endothelial function caused by high-fat meal
31  Atherosclerosis timeline
32  Some features of vulnerable plaque
33  Patients dying with stable versus unstable coronary syndromes: Atheromas have varying composition
34  Role of LDL-C in plaque formation and progression
35  Clinical viewpoints on plaques
36  Progression of atherosclerosis observed in 307 repeat angiographies post-CABG
37  Clinical studies summary: Angiography in infarct-related artery
38  PCI vs medical Rx for angina
39  Complementary effect of major therapies on 3 vital Rx goals
40  Coronary artery disease: Should plaque stabilization be a primary goal?
41  LDL-C reduction with statins
42  Target LDL-C levels for initiating dietary therapy: Are they realistic?
43  Target LDL-C levels for initiating drug therapy: Are they realistic?
44  Treatment decisions based on LDL-C levels in adults with diabetes
45  Risk factors for CAD: NCEP guidelines for adults
46  Dietary therapy for patients at risk for CAD
47  Major classes of drugs to reduce lipids
48  Achieving NCEP goals for LDL-C
49  Achieving NCEP goals for LDL-C
50  Benefits of aggressive LDL-C lowering
51  Post-CABG: Aggressive vs moderate LDL-C reduction
52  Post-CABG: Aggressive vs moderate LDL-C reduction
53  Post-CABG: Aggressive vs moderate LDL-C reduction
54  Post-CABG: Angiographic vein graft outcomes
55  Post-CABG: Event rates by cholesterol group
56  Post-CABG: Study summary
57  Post-CABG: Aggressive LDL-C reduction benefits patients with other CV risk factors
58  CURVES: Study design
59  CURVES: Study methodology
60  CURVES: Clinical characteristics
61  CURVES: Comparative LDL-C reductions across dose ranges
62  CURVES: Comparative efficacy of statins
63  Patients reaching the NCEP-recommended LDL-C concentrations with statin treatment
64  AVERT: Atorvastatin VErsus Revascularization Treatments
65  AVERT: Study rationale
66  AVERT: Major exclusion criteria
67  AVERT: Overview of study procedures
68  AVERT: Primary efficacy assessment
69  AVERT: Secondary efficacy assessments
70  AVERT: Baseline patient characteristics
71  AVERT: Ischemic events at 18 months
72  AVERT: Ischemic events at 18 months
73  AVERT: Time to first ischemic event
74  AVERT: Incidence of first ischemic event by time
75  AVERT: Summary of lipid parameters
76  AVERT: Safety evaluation
77  AVERT: Summary
78  Revascularization and lipid lowering
79  Revascularization and plaque pathology
80  Continuum of care
81  ACT
82  Clinical challenge: Aggressively ↓ LDL-C to ↓ CHD events
83  Summary: Postintervention action plan
84  Postintervention care timeline
85  Postintervention care timeline
86  Postintervention care timeline



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