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Slide Lecture Programs
2000 Core Curriculum
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The endothelium: New insights into the origins and treatment of CAD
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August 31, 2000
Table of Contents - 119 slides
No.
Title
1
The endothelium: New insights into the origins and treatment of CAD
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2
Program overview
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3
The endothelium maintains vascular health
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4
Unifying model: Endothelial dysfunction to CVD
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5
Physiology of NO in the human coronary and peripheral vasculature
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6
Physiology of NO in the human coronary and peripheral vasculature: Mechanisms of NO release
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7
Atherosclerosis timeline
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8
Therapeutic strategies for the treatment of endothelial function
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9
Candidates for therapies to enhance endothelial function
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10
Brachial FMD predicts coronary endothelial function
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11
Exercise improves coronary endothelial function in CAD
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12
Vitamin E and endothelial function in smokers
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13
Oral omega-3 fatty acids improve endothelial function in hypercholesterolemia
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14
Estrogen and vitamin E effects in postmenopausal women
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15
Tissue ACE inhibition and endothelial function
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16
Tetrahydrobiopterin supplementation restores endothelial function in smokers
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17
Effects of antihypertensive agents on endothelial function in postmenopausal women
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18
Spironolactone improves endothelial function in CHF
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19
Improving endothelial function: Most compelling data
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20
Components and major actions of the renin angiotensin system
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21
Vasculoprotective effects of angiotensin-(1-7)
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22
ACE metabolizes Ang-(1-7) into Ang-(1-5): Effect with and without ACE inhibition
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23
ACE and endothelial function
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24
Mechanisms for the effects of ACE inhibition on endothelial dysfunction
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25
Potential benefits of suppressing cardiac ACE
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26
Mechanisms of cardiac RAS activation in cardiac remodeling
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27
Possible mechanisms of endothelial dysfunction in heart failure
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28
Effect of experimental heart failure on cardiac ACE activity
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29
Genetic evidence that cardiac ACE correlates with experimental infarct size
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30
Neointima formation: Correlation with blood pressure and residual serum and tissue ACE after ACE-I
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31
ACE inhibitors and fibrinolysis
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32
Vasculoprotective effects of tissue ACE inhibition
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33
Cardiovascular role of bradykinin as determined by knockout mice
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34
ACE inhibition increases vasodilation by a bradykinin mechanism in response to flow-mediated dilation
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35
Effects of ACE-I vs other antihypertensive agents on endothelial function in hypertensive patients
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36
ACE inhibitors and endothelial function: Evidence for the role of NO and bradykinin
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37
ACE inhibitors upregulate b-adrenergic receptors on cardiac myocytes by a bradykinin mechanism
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38
Correlation between endothelial function and hypertension
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39
Correlation between endothelial function and atherosclerosis
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40
Severe endothelial dysfunction associated with increased CV risk in patients with mild CAD
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41
Endothelial dysfunction predicts cardiovascular events: 5-year follow-up in patients with angina
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42
Endothelial function vs clinical outcome in patients with CAD
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43
Carotid plaque is a marker of CV risk
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44
Carotid atherosclerosis and systolic blood pressure
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45
New treatment approach to hypertension
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46
JNC-VI guidelines: Risk stratification and treatment
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47
JNC-VI guidelines: Compelling indications
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48
Vascular changes and CV risk factors in borderline hypertension (BP > 140/90 mm Hg)
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49
Reduction in systolic blood pressure with quinapril by patient age
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50
Efficacy of quinapril vs captopril in moderate-to-severe hypertension
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51
Combined and distinct vascular effects of ACE-I and statins: Effect on blood pressure
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52
Combined and distinct vascular effects of ACE-I and statins: Effect on hemodynamic reactivity
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53
Blood pressure control after 8 weeks of quinapril: Effect of age and gender
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54
Blood pressure control after 8 weeks of quinapril: Effect of race
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55
ACE inhibitor therapy: Effect on vascular and cardiac structure in hypertensive patients
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56
Quinapril reduces blood pressure and vascular hypertrophy
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57
Effect of quinapril on ST-segment depression in patients with angina
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58
Quinapril improves fasting glucose levels in type 2 diabetes
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59
Quinapril + HCTZ fixed combinations trials: Design
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60
Quinapril 10 mg/HCTZ 12.5 mg study: Results
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61
Quinapril 20 mg/HCTZ 12.5 mg study: Efficacy
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62
UKPDS: Importance of tight control of both BP and glycemia on risk of diabetes complications
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63
Change in vascular ACE density after arterial injury and effect of quinapril to prevent restenosis
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64
Quinaprilat improves blood flow in ischemic myocardium
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65
Quinaprilat reduces total coronary resistance: Ischemic regions
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66
Quinaprilat reduces total coronary resistance: Non-ischemic regions
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67
ATIME: Slower dose escalation of quinapril improves blood pressure control
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68
Hypercholesterolemia induces AT
1
receptor expression
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69
Relative risks for heart failure: Framingham Study
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70
Progression of hypertension to LVH and heart failure
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71
Effect of ACE inhibition on mortality and morbidity in heart failure patients: An analysis of 32 trials
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72
LVH regression: Changes in left ventricular mass index with 4 drug classes
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73
LVH is normalized in most patients with long-term quinapril treatment
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74
Effect of ACE inhibition on FMD in patients with heart failure
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75
Increasing dosages of enalaprilat did not affect FMD
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76
Effect of quinapril on b-receptor function in heart failure
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77
Effect of quinapril on
b
-receptor density
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78
ATLAS: High- vs low-dose ACE inhibition in heart failure?study design
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79
ATLAS: High-dose ACE-I reduces adverse outcomes in heart failure
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80
ACE inhibitors in CHF: Are maximally recommended doses sufficient?
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81
Comparative inhibition of plasma and tissue ACE
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82
Relative potency of ACE inhibitors in plasma and tissue
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83
Relative potency of ACE inhibitors in human heart and lung
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84
Comparative dissociation rates of ACE inhibitors from human atrial membranes
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85
ACE inhibition: Pharmacokinetic overview
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86
Differential effects of quinapril and losartan on superoxide production in endothelial cells
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87
ACE inhibitors and ARBs: Comparative effects on postprandial endothelial function
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88
Comparative effect of ACE inhibition and AR blockade on fibrinolytic balance
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89
Quinapril but not losartan improves survival in cardiomyopathic hamsters
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90
ACE inhibitors vs ARBs in heart failure trials: Study characteristics
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91
RESOLVD: Clinical results
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92
ELITE II: Study design
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93
ELITE II: Study results
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94
ACE inhibitors vs ARBs in heart failure: Effects on mortality and hospitalization
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95
ELITE I substudy compares the effects of ACE inhibition and AR blockade on LV remodeling
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96
ACE inhibitors vs ARBs in heart failure: Clinical summary
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97
Tissue ACE trials in patients with CAD and preserved LV function
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98
TREND: Endothelial function and ACE inhibition
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99
TREND: Influence of smoking status on progression of endothelial dysfunction
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100
TREND: Effect of smoking and ACE-I on coronary artery segment diameter
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101
BANFF: Effect of ACE inhibitors vs other cardiovascular agents on FMD
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102
BANFF: Results by ACE genotype
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103
Trials of ACE inhibition effects on outcomes following revascularization
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104
APRES: Effect of ramipril on cardiac outcomes
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105
QUO VADIS: Effects of quinapril on ischemia
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106
QUO VADIS: Chronic ACE inhibition and Ang II formation in internal mammary artery segments
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107
New tissue ACE trials: Differences in scope
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108
QUIET: Design and methods
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109
QUIET: Cardiac death, nonfatal MI, or VT/VF
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110
QUIET: Effect of quinapril on CAD progression according to LDL-C level
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111
HOPE: Design and methods
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112
HOPE: Primary outcome (MI, stroke, CV death)
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113
HOPE: Risk reduction with ACE inhibition
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114
HOPE: Risk reduction in diabetic cohort
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115
HOPE: Baseline SBP vs global endpoint
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116
Tissue ACE trials in patients with CAD and preserved LV function: Benefits observed
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117
Tissue ACE trials in patients with CAD and preserved LV function: Implications for clinical practice
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118
EUROPA: An upcoming tissue ACE trial
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119
EUROPA substudies: Confirmation of pathophysiologic concepts
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