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Slide Lecture Programs
2000 Core Curriculum
The endothelium: New insights into the origins and treatment of CAD
August 31, 2000


Table of Contents - 119 slides

No.  Title
1  The endothelium: New insights into the origins and treatment of CAD
2  Program overview
3  The endothelium maintains vascular health
4  Unifying model: Endothelial dysfunction to CVD
5  Physiology of NO in the human coronary and peripheral vasculature
6  Physiology of NO in the human coronary and peripheral vasculature: Mechanisms of NO release
7  Atherosclerosis timeline
8  Therapeutic strategies for the treatment of endothelial function
9  Candidates for therapies to enhance endothelial function
10  Brachial FMD predicts coronary endothelial function
11  Exercise improves coronary endothelial function in CAD
12  Vitamin E and endothelial function in smokers
13  Oral omega-3 fatty acids improve endothelial function in hypercholesterolemia
14  Estrogen and vitamin E effects in postmenopausal women
15  Tissue ACE inhibition and endothelial function
16  Tetrahydrobiopterin supplementation restores endothelial function in smokers
17  Effects of antihypertensive agents on endothelial function in postmenopausal women
18  Spironolactone improves endothelial function in CHF
19  Improving endothelial function: Most compelling data
20  Components and major actions of the renin angiotensin system
21  Vasculoprotective effects of angiotensin-(1-7)
22  ACE metabolizes Ang-(1-7) into Ang-(1-5): Effect with and without ACE inhibition
23  ACE and endothelial function
24  Mechanisms for the effects of ACE inhibition on endothelial dysfunction
25  Potential benefits of suppressing cardiac ACE
26  Mechanisms of cardiac RAS activation in cardiac remodeling
27  Possible mechanisms of endothelial dysfunction in heart failure
28  Effect of experimental heart failure on cardiac ACE activity
29  Genetic evidence that cardiac ACE correlates with experimental infarct size
30  Neointima formation: Correlation with blood pressure and residual serum and tissue ACE after ACE-I
31  ACE inhibitors and fibrinolysis
32  Vasculoprotective effects of tissue ACE inhibition
33  Cardiovascular role of bradykinin as determined by knockout mice
34  ACE inhibition increases vasodilation by a bradykinin mechanism in response to flow-mediated dilation
35  Effects of ACE-I vs other antihypertensive agents on endothelial function in hypertensive patients
36  ACE inhibitors and endothelial function: Evidence for the role of NO and bradykinin
37  ACE inhibitors upregulate b-adrenergic receptors on cardiac myocytes by a bradykinin mechanism
38  Correlation between endothelial function and hypertension
39  Correlation between endothelial function and atherosclerosis
40  Severe endothelial dysfunction associated with increased CV risk in patients with mild CAD
41  Endothelial dysfunction predicts cardiovascular events: 5-year follow-up in patients with angina
42  Endothelial function vs clinical outcome in patients with CAD
43  Carotid plaque is a marker of CV risk
44  Carotid atherosclerosis and systolic blood pressure
45  New treatment approach to hypertension
46  JNC-VI guidelines: Risk stratification and treatment
47  JNC-VI guidelines: Compelling indications
48  Vascular changes and CV risk factors in borderline hypertension (BP > 140/90 mm Hg)
49  Reduction in systolic blood pressure with quinapril by patient age
50  Efficacy of quinapril vs captopril in moderate-to-severe hypertension
51  Combined and distinct vascular effects of ACE-I and statins: Effect on blood pressure
52  Combined and distinct vascular effects of ACE-I and statins: Effect on hemodynamic reactivity
53  Blood pressure control after 8 weeks of quinapril: Effect of age and gender
54  Blood pressure control after 8 weeks of quinapril: Effect of race
55  ACE inhibitor therapy: Effect on vascular and cardiac structure in hypertensive patients
56  Quinapril reduces blood pressure and vascular hypertrophy
57  Effect of quinapril on ST-segment depression in patients with angina
58  Quinapril improves fasting glucose levels in type 2 diabetes
59  Quinapril + HCTZ fixed combinations trials: Design
60  Quinapril 10 mg/HCTZ 12.5 mg study: Results
61  Quinapril 20 mg/HCTZ 12.5 mg study: Efficacy
62  UKPDS: Importance of tight control of both BP and glycemia on risk of diabetes complications
63  Change in vascular ACE density after arterial injury and effect of quinapril to prevent restenosis
64  Quinaprilat improves blood flow in ischemic myocardium
65  Quinaprilat reduces total coronary resistance: Ischemic regions
66  Quinaprilat reduces total coronary resistance: Non-ischemic regions
67  ATIME: Slower dose escalation of quinapril improves blood pressure control
68  Hypercholesterolemia induces AT1 receptor expression
69  Relative risks for heart failure: Framingham Study
70  Progression of hypertension to LVH and heart failure
71  Effect of ACE inhibition on mortality and morbidity in heart failure patients: An analysis of 32 trials
72  LVH regression: Changes in left ventricular mass index with 4 drug classes
73  LVH is normalized in most patients with long-term quinapril treatment
74  Effect of ACE inhibition on FMD in patients with heart failure
75  Increasing dosages of enalaprilat did not affect FMD
76  Effect of quinapril on b-receptor function in heart failure
77  Effect of quinapril on b-receptor density
78  ATLAS: High- vs low-dose ACE inhibition in heart failure?study design
79  ATLAS: High-dose ACE-I reduces adverse outcomes in heart failure
80  ACE inhibitors in CHF: Are maximally recommended doses sufficient?
81  Comparative inhibition of plasma and tissue ACE
82  Relative potency of ACE inhibitors in plasma and tissue
83  Relative potency of ACE inhibitors in human heart and lung
84  Comparative dissociation rates of ACE inhibitors from human atrial membranes
85  ACE inhibition: Pharmacokinetic overview
86  Differential effects of quinapril and losartan on superoxide production in endothelial cells
87  ACE inhibitors and ARBs: Comparative effects on postprandial endothelial function
88  Comparative effect of ACE inhibition and AR blockade on fibrinolytic balance
89  Quinapril but not losartan improves survival in cardiomyopathic hamsters
90  ACE inhibitors vs ARBs in heart failure trials: Study characteristics
91  RESOLVD: Clinical results
92  ELITE II: Study design
93  ELITE II: Study results
94  ACE inhibitors vs ARBs in heart failure: Effects on mortality and hospitalization
95  ELITE I substudy compares the effects of ACE inhibition and AR blockade on LV remodeling
96  ACE inhibitors vs ARBs in heart failure: Clinical summary
97  Tissue ACE trials in patients with CAD and preserved LV function
98  TREND: Endothelial function and ACE inhibition
99  TREND: Influence of smoking status on progression of endothelial dysfunction
100  TREND: Effect of smoking and ACE-I on coronary artery segment diameter
101  BANFF: Effect of ACE inhibitors vs other cardiovascular agents on FMD
102  BANFF: Results by ACE genotype
103  Trials of ACE inhibition effects on outcomes following revascularization
104  APRES: Effect of ramipril on cardiac outcomes
105  QUO VADIS: Effects of quinapril on ischemia
106  QUO VADIS: Chronic ACE inhibition and Ang II formation in internal mammary artery segments
107  New tissue ACE trials: Differences in scope
108  QUIET: Design and methods
109  QUIET: Cardiac death, nonfatal MI, or VT/VF
110  QUIET: Effect of quinapril on CAD progression according to LDL-C level
111  HOPE: Design and methods
112  HOPE: Primary outcome (MI, stroke, CV death)
113  HOPE: Risk reduction with ACE inhibition
114  HOPE: Risk reduction in diabetic cohort
115  HOPE: Baseline SBP vs global endpoint
116  Tissue ACE trials in patients with CAD and preserved LV function: Benefits observed
117  Tissue ACE trials in patients with CAD and preserved LV function: Implications for clinical practice
118  EUROPA: An upcoming tissue ACE trial
119  EUROPA substudies: Confirmation of pathophysiologic concepts



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