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Slide Lecture Programs
2007 Core Curriculum
Contemporary Management of Cardiometabolic Risk
May 15, 2007


Table of Contents - 105 slides

No.  Title
1  Contemporary Management of Cardiometabolic Risk
2  A continuing epidemic: 2 of 3 US adults are overweight or obese
3  Parallel epidemics of diabetes and obesity
4  Defining cardiometabolic risk
5  Associations of adiposity with CVD
6  Adiposity predicts mortality
7  Adiposity associated with premature MI
8  Majority of patients undergoing PCI are overweight or obese
9  Adverse consequences of chronic adiposity and ectopic fat
10  Epicardial adipose tissue may be increased in visceral obesity
11  Adiposity in the development of NASH
12  Visceral vs subcutaneous adiposity
13  Neutral effect of liposuction on cardiometabolic risk factors
14  Central adiposity: Better marker of CVD than BMI
15  A new vital sign: Waist circumference
16  Continued burden of disease
17  Adiposity in CVD
18  Role of adipose tissue in atherogenesis
19  Elevated FFA contribute to hypertension, dyslipidemia, and insulin resistance
20  Energy homeostasis is linked to immune balance
21  Weight gain induces inflammatory changes in adipose tissue
22  Adipose tissue: An endocrine organ
23  Adiponectin associated with decreased risk of MI
24  Beneficial associations of adiponectin
25  Low adiponectin in visceral adiposity
26  Even moderate weight loss may improve cardiometabolic risk
27  Summary
28  The Endocannabinoid System
29  Cannabinoid classification with selected examples
30  ECS: Widely distributed with multiple cardiometabolic effects
31  Potential therapeutic implications of CB1 receptor blockade
32  Circulating 2-AG elevated in persons with visceral vs sc adiposity
33  CB1 receptor blockade blunts overeating in rats
34  CB1 receptor blockade: Weight reduction independent of food intake in obese mice
35  CB1 receptor blockade modulates adipocyte function in mice
36  CB1 receptors modulate liver lipogenesis in mice
37  CB1 receptor blockade increases skeletal muscle glucose uptake in obese mice
38  CB1 receptor blockade and mood: Range of effects observed in animal models
39  Endocannabinoid system overview
40  Managing Cardiometabolic Risk
41  NHLBI guidelines: Adiposity assessment
42  BMI classifications
43  Measuring waist circumference
44  Diagnostic criteria for metabolic syndrome
45  NHLBI guidelines: Weight loss goals
46  Guide to adiposity management
47  NHLBI guidelines: Lifestyle modification
48  Some moderate-intensity physical activities
49  3-Week diet + exercise regimen yields favorable metabolic changes
50  Physical activity may reduce CV and all-cause mortality
51  Lifestyle modification associated with diabetes prevention
52  DPP: Benefit of diet + exercise or metformin on diabetes prevention in at-risk patients
53  Popular dietary programs: Effective yet difficult to maintain
54  Look AHEAD: Study design
55  NHLBI guidelines: Pharmacologic therapy
56  Pharmacologic weight management options
57  Efficacy of orlistat as adjunct to lifestyle modification
58  Efficacy of sibutramine as adjunct to lifestyle modification
59  Effects of sibutramine and lifestyle modification on cardiometabolic risk factors
60  SCOUT: Study design
61  NHLBI guidelines: Weight loss surgery
62  SOS: Bariatric surgery-associated improvements in cardiometabolic risk
63  Improved Framingham risk score following bariatric surgery
64  Clinical evaluation of CB1 receptor blockade
65  Rimonabant In Obesity (RIO) program
66  RIO program: Improved cardiometabolic risk factors at 1 year
67  RIO program: Decreased metabolic syndrome incidence
68  RIO program: Safety and tolerability
69  RIO program: No significant effect on mood
70  RIO program: Mood at 1 year
71  RIO clinical trial program efficacy summary
72  SERENADE: Study design
73  SERENADE: Change in A1C at 6 months
74  Summary
75  Ongoing trials with rimonabant in abdominal adiposity
76  Current and emerging pharmacologic combinations for treating cardiometabolic risk
77  Managing cardiometabolic risk
78  Data Supplement
79  RIO-Europe: Study design
80  RIO-Europe: Treatment effect on weight and waist circumference
81  RIO-Europe: Treatment effect on lipids
82  RIO-Europe: Adverse events
83  RIO-Lipids: Study design
84  RIO-Lipids: Treatment effect on weight and WC
85  RIO-Lipids: Treatment effect on lipids
86  RIO-Lipids: Rimonabant weight-independent effect on adiponectin
87  RIO-Lipids: Adverse events
88  RIO-Diabetes: Study design
89  RIO-Diabetes: Treatment effect on weight and waist circumference
90  RIO-Diabetes: Treatment effect on lipids
91  RIO-Diabetes: Treatment effect on glucose metabolism
92  RIO-Diabetes: Adverse events
93  RIO-North America: Study design
94  RIO-North America: Weight change by treatment assignment
95  RIO-North America: Waist circumference by treatment assignment
96  RIO-North America: Treatment effect on lipids at 1 year
97  RIO-North America: Weight-independent and weight-dependent effects on lipids
98  RIO-North America: Weight-independent and weight-dependent effects on insulin and IR
99  RIO-North America: Adverse events
100  RIO-North America: Adverse events, cont'd
101  Obesity program depression-related events: Overall incidences
102  Completed phase 2 and 3 studies as of March 2007: All suicidality-related events
103  Rimonabant clinical safety: Summary
104  ACOMPLIA: European product information
105  ACOMPLIA: European product information, cont'd



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